Utility of renal resistive index measurement in juvenile systemic lupus erythematosus: a cross-sectional single-center study.

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Kisla Ekinci R. M., Cakir Pekoz B., Taner S.

Clinical rheumatology, cilt.42, sa.10, ss.2849-2854, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 10
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10067-023-06711-8
  • Dergi Adı: Clinical rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.2849-2854
  • Çukurova Üniversitesi Adresli: Evet

Özet

Introduction Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with a complex etiopathogenesis.

Renal involvement is the most common and devastating complication of the disease. Renal resistive index (RRI) was

suggested as a noninvasive biomarker for lupus nephritis in previous studies. This is the first study to investigate the role of

RRI measurement in juvenile SLE patients.

Methods This cross-sectional study included 25 juvenile SLE patients and 25 healthy controls. Demographic and clinical

features were recruited from the medical files of the patients. RRI measurements were performed with color Doppler

ultrasonography from intrarenal arteries when Doppler angles were 30–60 in right and left kidneys.

Results Of 25 (19 female, 6 male) SLE patients, nineteen (76%) patients had urinary abnormalities during follow-up, and

renal biopsy was performed in 14 patients, of which 9 (64.3%) had class 2 and 5 (35.7%) had class 4 lupus nephritis. RRI was

found significantly higher in SLE group than healthy controls. RRI did not differ between SLE patients, grouped according

to the presence of renal involvement and class IV lupus nephritis. RRI did not correlate with serum creatinine, GFR, spot

urine protein/creatinine, and albumin/creatinine ratio.

Conclusions Although RRI was found significantly higher in juvenile SLE, it is not affected by GFR, proteinuria level, or

the renal biopsy results, even the presence of proliferative nephritis. The underlying pathogenetic mechanisms of increased

RRI in SLE should be clarified in further studies.