Combined chemotherapy in pleurectomized malignant pleural mesothelioma patients

Hasturk S., Tastepe I., Unlu M., Cetin G., Baris Y.

JOURNAL OF CHEMOTHERAPY, cilt.8, ss.159-164, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 8 Konu: 2
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1179/joc.1996.8.2.159
  • Sayfa Sayıları: ss.159-164


A phase II clinical trial of 20 cancer patients who presented with malignant pleural mesothelioma (MPM) between November 1991 and April 1993 was conducted. Of the histologically proven cases, 16 (80%) were epitheloid and 4 (20%) were mixed type MPM. Patients were treated with mitomycin C, cisplatin, and alpha interferon after pleurectomy. Our schedule consisted of 10 mg/m(2) mitomycin C i.v. infusion, 50 mg/m(2) cisplatin i.v. infusion, 10 mil Ur-alpha interferon i.m. and 10 mil Ur-alpha interferon i.v. infusion on the first day of treatment. Patients were given a mean of 4.5 chemotherapy cycles (range:2-6).