Combined chemotherapy in pleurectomized malignant pleural mesothelioma patients

Hasturk S., Tastepe I., Unlu M., Cetin G., Baris Y.

JOURNAL OF CHEMOTHERAPY, vol.8, no.2, pp.159-164, 1996 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 1996
  • Doi Number: 10.1179/joc.1996.8.2.159
  • Title of Journal : JOURNAL OF CHEMOTHERAPY
  • Page Numbers: pp.159-164


A phase II clinical trial of 20 cancer patients who presented with malignant pleural mesothelioma (MPM) between November 1991 and April 1993 was conducted. Of the histologically proven cases, 16 (80%) were epitheloid and 4 (20%) were mixed type MPM. Patients were treated with mitomycin C, cisplatin, and alpha interferon after pleurectomy. Our schedule consisted of 10 mg/m(2) mitomycin C i.v. infusion, 50 mg/m(2) cisplatin i.v. infusion, 10 mil Ur-alpha interferon i.m. and 10 mil Ur-alpha interferon i.v. infusion on the first day of treatment. Patients were given a mean of 4.5 chemotherapy cycles (range:2-6).