In this case, the diagnosis and treatment of atypical dermatitis caused by Demodex canis was evaluated in a-5 year old English pointer. The disease defined as atypical dermatitis due to clinical, laboratory, bacteriological, parasitological and histopatological results. Demodex canis, beta-hemolytic Staphylococcus aureus and Microsporum canis were isolated and identified on the skin scrapings, biopsy specimens and swab. The dog was treated for 4 months, given bath of ketoconazole and benzoyl peroxide shampoo, twice in a week, ivermectin 0.6 mg/kg, SC, three days interval, cefaperazone-sulbactam (22 mg/kg, IM) daily for only 10 days and followed by cefquinom (2 mg/kg IM) daily for the rest of the treatment period of 3.5 months, and ketaconazole (10 mg/kg, PO,4 months) daily. As a result, atypical dermatitis caused by Demodex canis should be treated for longer duration with no complications and with successful outcome at 3 days interval.