Insertion/deletion polymorphism of the angiotensin converting enzyme gene in coronary artery disease in southern Turkey

ACARTURK E., ATTILA G., BOZKURT A., AKPINAR O., MATYAR S., Seydaoglu G.

JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, cilt.38, sa.4, ss.486-490, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 4
  • Basım Tarihi: 2005
  • Dergi Adı: JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.486-490
  • Anahtar Kelimeler: ACE, allele, coronary artery disease, gene polymorphism, southern Turkey, DELETION POLYMORPHISM, MYOCARDIAL-INFARCTION, HEART-DISEASE, RISK-FACTOR, D ALLELE, SYSTEM, ASSOCIATION, RESTENOSIS, EXTENT
  • Çukurova Üniversitesi Adresli: Evet

Özet

Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 3580, mean 54.3 +/- 9.8 years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9%). However, in patients with CAD the frequency of 11 genotype was lower whereas DD genotype was higher compared to the controls (p < 0.05). The number of D allele carrying subjects were also higher (p < 0.05) in CAD patients. The logistic regression analysis indicated that the ACE D allele is an independent risk factor (odds ratio = 1.48, 95% CI = 1.01-2.18, p < 0.05). In conclusion, the I/D polymorphism of ACE gene (carrying D allele) is an independent risk factor for CAD in the studied Turkish population.