Systemic immune-inflammation index predicting survival outcome in patients with classical Hodgkin lymphoma

Mirili C. , PAYDAŞ S. , Kapukaya T. K. , YILMAZ A.

BIOMARKERS IN MEDICINE, vol.13, no.18, pp.1565-1575, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 18
  • Publication Date: 2019
  • Doi Number: 10.2217/bmm-2019-0303
  • Title of Journal : BIOMARKERS IN MEDICINE
  • Page Numbers: pp.1565-1575


Aim: To evaluate the prognostic significance of neutrophil lymphocyte ratio, prognostic nutritional index, systemic immune-inflammation index (SII) and B2M in Hodgkin Lymphoma (HL). Materials & methods: Neutrophil-lymphocyte ratio, prognostic nutritional index, SII and B2M were analyzed to assess their prognostic value via the Kaplan-Meier method and Cox regression analysis in 122 HL patients, retrospectively. Results: SII was found to have the highest area under curve and the most sensitive and specific among all markers. In univariate analyses, all four parameters were prognostic for overall survival and progression-free survival, in multivariate analyzes only SII was found to be independent factors for both of them. Conclusion: SII can be suggested as a novel independent and better prognostic factor for predicting overall survival and progression-free survival in HL.