We present a very rare case of endogenous panophthalmitis in a postpartum patient. A 31-year-old woman was admitted with vision loss and pain in the right eye for two days that began the day after the delivery. Her ophthalmologic examination revealed panophthalmitis and she was hospitalized for treatment and investigation. Despite intensive medication corneal melting and spontaneous perforation occurred, so evisceration had to be performed. Sphingomonas paucimobilis, an opportunistic infection agent, was isolated in the conjunctival swab and evisceration specimen cultures of the patient. It is known that immune system is influenced and inflammatory responses are altered in pregnants and puerperants, so any symptom of eye infection should not be ignored in peripartum and puerperium periods.