Ornidazole Incorporated Chitosan Nanoparticles for Ocular Application


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Basaran E. , Senel B., Kirimlioglu G. Y. , Guven U. M. , Yazan Y.

LATIN AMERICAN JOURNAL OF PHARMACY, vol.34, no.6, pp.1180-1188, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 6
  • Publication Date: 2015
  • Title of Journal : LATIN AMERICAN JOURNAL OF PHARMACY
  • Page Numbers: pp.1180-1188

Abstract

Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there is a need for developing efficient modern drug delivery systems. Main attempt in this study was to extend the interaction of the carrier with negatively charged ocular surfaces for enhanced penetration from both corneal and non-corneal sites in order to improve ocular bioavailability. Self-cationic, mucoadhesive and permeation-enhancing characters make chitosan an ideal polymer for ocular application of active agents. In this study ornidazole incorporated chitosan nanoparticles were prepared by spray-drying process. In vitro characterization showed that enhanced ocular bioavailability could be achieved by non-toxic chitosan nanoparticles.