Retinoic acid (RA) regulates 17 beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: Interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism


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Cheng Y. , Yin P., Xue Q., Yilmaz B., Dawson M. I. , Bulun S. E.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.93, ss.1915-1923, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 93 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1210/jc.2007-1536
  • Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Sayfa Sayıları: ss.1915-1923

Özet

Context: The enzyme 17 beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) exerts a local antiestrogenic effect by metabolizing biologically active estradiol to inactive estrone in endometrial epithelial cells. Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known.