Retinoic acid (RA) regulates 17 beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: Interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism

Cheng, MEHMET; Yin, Ping; Xue, Qing; Yilmaz, Bertan; Dawson, Marcia; Bulun, Serdar

doi:10.1210/jc.2007-1536

Retinoic acid (RA) regulates 17 beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: Interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism

Cheng Y., Yin P., Xue Q., Yilmaz B., Dawson M. I., Bulun S. E.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.93, sa.5, ss.1915-1923, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 93 Sayı: 5
Basım Tarihi: 2008
Doi Numarası: 10.1210/jc.2007-1536
Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1915-1923
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Çukurova Üniversitesi Adresli: Hayır

Özet

Context: The enzyme 17 beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) exerts a local antiestrogenic effect by metabolizing biologically active estradiol to inactive estrone in endometrial epithelial cells. Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known.