Retinoic acid (RA) regulates 17 beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: Interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism

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Cheng Y., Yin P., Xue Q., Yilmaz B., Dawson M. I., Bulun S. E.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.93, sa.5, ss.1915-1923, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1210/jc.2007-1536
  • Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1915-1923
  • Çukurova Üniversitesi Adresli: Hayır

Özet

Context: The enzyme 17 beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) exerts a local antiestrogenic effect by metabolizing biologically active estradiol to inactive estrone in endometrial epithelial cells. Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known.