Effect of caffeic acid phenethyl ester on corneal neovascularization in rats

Totan Y., Aydın E., Çekiç O., Dağlioğlu M., Borazan M., Daglioglu K.

CURRENT EYE RESEARCH, vol.23, no.4, pp.291-297, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2001
  • Doi Number: 10.1076/ceyr.23.4.291.5453
  • Journal Name: CURRENT EYE RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.291-297
  • Çukurova University Affiliated: Yes

Abstract

Purpose. Caffeic acid phenethyl ester (CAPE), a biologically active component of propolis from honeybee hives, has potent antiinflammatory and antioxidant properties. We aimed to evaluate the ability of topically applied CAPE in comparison with known steroidal (dexamethasone sodium phosphate) and nonsteroidal (indomethacin) topical agents to reduce corneal neovascularization (CNV) induced by silver nitrate cauterization in rats.