Prophylactic red blood cell exchange may be beneficial in the management of sickle cell disease in pregnancy

Asma S., Kozanoglu I., Tarim E., Sariturk C., Gereklioglu Ç. , Akdeniz A., ...More

TRANSFUSION, vol.55, no.1, pp.36-44, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1111/trf.12780
  • Title of Journal : TRANSFUSION
  • Page Numbers: pp.36-44


BackgroundSickle cell disease (SCD) is associated with chronic hemolysis and painful episodes. Pregnancy accelerates sickle cell complications, including prepartum and postpartum vasoocclusive crisis, pulmonary complications, and preeclampsia or eclampsia. Fetal complications include preterm birth and its associated risks, intrauterine growth restriction, and a high rate of perinatal mortality. The purpose of this study was to evaluate pregnancy outcomes in patients with SCD who underwent planned preventive red blood cell exchange (RBCX).