Synthesis of heterocycles via sequential Pd/Ru-catalysed allene insertion-nucleophile incorporation-olefin metathesis

DÖNDAŞ H. A., Balme G., Blandine C., Grigg R., Hodgeson A., Morris J., ...More

TETRAHEDRON LETTERS, vol.42, no.49, pp.8673-8675, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 49
  • Publication Date: 2001
  • Doi Number: 10.1016/s0040-4039(01)01810-x
  • Journal Name: TETRAHEDRON LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8673-8675
  • Çukurova University Affiliated: No

Abstract

A novel sequential palladium/ruthenium-catalysed three-component process is described involving allenylation of aryl/heteroaryl iodides to generate (pi -allyl) palladium species which are intercepted by nitrogen nucleophiles to afford 1,6- and 1,7-dienes. Subsequent ring-closing metathesis affords N-heterocycles in good yield. (C) 2001 Elsevier Science Ltd. All rights reserved.