Lysimeters are considered the standard for evapotranspiration (ET) measurements. However, these units are often not replicated and are few in number at any given location. The Bowen ratio-energy balance (BREB) is a micrometeorological method often used to estimate ET because of its simplicity, robustness, and cost. In this paper, ET of irrigated soybean (Glycine max L.) was directly measured by weighing lysimeter and estimated by BREB method over a growing season in a semi-arid climate of eastern Mediterranean region. The study was conducted in Adana-Turkey during the summer of 2009 on a 0.12 ha area with a weighing lysimeter (2.0 x 2.0 x 2.5 m) located in the center of the field completely covered by well watered soybean where the prevailing direction of the wind and the upwind fetch was about 60 m. Cumulative evapotranspiration totals from the lysimeter and BREB methods were 354 and 405 mm, respectively. The BREB method showed a good performance for daily ET estimation when compared to values measured by lysimeter. This method, with a root mean square error (RMSE) of 0.79 mmd(-1) and a 0.96 index of agreement, over-estimates lysimetric measurements by 15%. The BREB method also performs well compared with lysimetric measurements for hourly ET, but produces overestimation of 14% with RMSE of 0.128 mmh(-1), and a 0.92 index of agreement.