130P Clinicopathologic determinants of prognosis in head and neck soft tissue sarcomas: A multi-factorial survival analysis

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Bayram E., Kıdı M. M., Kara İ. O., Şahin B.

ESMO OPEN, cilt.10, sa.3, ss.23-24, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.esmoop.2025.104443
  • Dergi Adı: ESMO OPEN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.23-24
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background: Head and neck soft tissue sarcomas (HNSTS) are a group of rare heterogeneous

tumours arising from embryonic mesoderm. They comprise <1% of all

head and neck malignancies and 5e15% of all sarcomas with most head and neck

sarcomas arising from soft tissues. As a result, the prognostic determinants of this

disease have not yet been fully elucidated. This study aimed to examine the prognostic

indicators and oncological outcomes associated with HNSTS.

Methods: Between 2014 and 20019, the medical records of 51 adult patients were

retrospectively evaluated. Potential prognostic factors were analyzed in relation to

overall survival (OS) and disease-free survival (DFS). Univariate and multivariate analyses

were conducted using the Cox proportional hazards model to identify clinicopathologic

factors associated with DFS and OS.

Results: Rhabdomyosarcoma was the most prevalent tumor type (24%), followed by

angiosarcoma (14%). The majority of the patients received treatment with the

doxorubicin and ifosfamide protocol. At 5 years, OS was 69%, and DFS was 59%.

Univariate analysis revealed that distant or lymph node metastasis at diagnosis,

surgical margins, and overall stage were statistically significant prognostic factors for

both OS and DFS. Multivariate analysis demonstrated that surgical margins remained

a statistically significant factor for DFS, while overall stage remained significant for OS.

Conclusions: This comprehensive analysis establishes surgical margins and overall

stage as independent prognostic factors in head and neck soft tissue sarcomas. The

findings demonstrate favorable long-term survival outcomes, with 5-year overall

survival reaching 69%. These results strongly support the critical importance of

achieving clear surgical margins and emphasize the necessity of accurate staging in

treatment planning. This evidence provides a robust foundation for clinical decisionmaking

in managing these rare but challenging neoplasms.