Akademik Veri Yönetim Sistemi
Animals, cilt.16, sa.6, 2026 (SCI-Expanded, Scopus)
In this study, we investigated the genomic basis of key body measurement and weight traits in Iraqi Awassi sheep using a multi-locus genome-wide association approach. A total of 315 yearling animals were phenotyped for body length, chest depth, heart girth, withers height, and body weight, and genotyped using the Ovine 50K SNP BeadChip. Genome-wide association analyses were performed within the BLUPmrMLM framework to improve the detection of loci with moderate-to-small effects. Significant associations were identified using an LOD-based threshold (LOD ≥ 5), followed by positional annotation of nearby genes and functional enrichment analyses to infer their potential biological relevance. Multiple genomic regions were associated with the evaluated traits. Among the most biologically plausible candidate genes were DST and CFAP299 for body length, ADAMTS8 for chest depth, ZFPM1 and OST4 for heart girth, CPEB2 for body weight, and ITGBL1, RBMS3, and THSD7B for withers height. Functional enrichment analyses indicated the involvement of pathways related to integrin-mediated signaling, focal adhesion and integrin complexes, extracellular matrix organization, and post-transcriptional regulation, suggesting coordinated effects of cell–matrix interactions and gene-expression regulation on body size and conformation. Overall, these findings refine the genomic landscape underlying body weight and morphometric variation in Awassi sheep and provide a focused set of loci for future validation and possible application in marker-assisted and genomic selection programs.