Investigation of anticarcinogenic and antioxidant effects of 4-methylimidazole

TAZEHKAND, Norizadeh; HAJIPOUR, O.; MORIDIKIA, F.; MORIDIKIA, A.; VALIPOUR, E.; YILMAZ, MEHMET; TOPAKTAŞ, MEHMET

doi:10.4149/bll_2017_029

Investigation of anticarcinogenic and antioxidant effects of 4-methylimidazole

TAZEHKAND N. M., HAJIPOUR O., MORIDIKIA F., MORIDIKIA A., VALIPOUR E., YILMAZ M. B., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.118, no.3, pp.149-152, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 118 Issue: 3
Publication Date: 2017
Doi Number: 10.4149/bll_2017_029
Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.149-152
Çukurova University Affiliated: Yes

Abstract

4-methylimidazole is widely used in pharmaceuticals, photographic and agricultural chemicals. The substance is extensively found in many human and animals foods. In this research, anticancer effect of the 4-MEI was studded using MIT test using MCF-7 cell line. Effect of the 4-MEI on apoptosis or necrosis was analyzed by DNA fragmentation assay using Swiss Albino rats as a model organism. Antioxidant effect of the substance was investigated by assaying protective effect of the substance on circular plasmid DNA against H2O2 as an oxidative agent.