Effect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study

Barlaz Us S., Sogut F., YILDIRIM M., Yetkin D., Yalin S., Yilmaz S. N., ...Daha Fazla

Cancer Investigation, cilt.37, sa.9, ss.489-500, 2019 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 9
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/07357907.2019.1662434
  • Dergi Adı: Cancer Investigation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.489-500
  • Anahtar Kelimeler: cell index, EAG1 channel, Imipramine, oxidative stress, prostate cancer, radiotherapy
  • Çukurova Üniversitesi Adresli: Evet

Özet

Prostate cancer is the most common cancer and leading cause of cancer death for males. Imipramine (IMI), which is a tricyclic antidepressant, has also been shown to has antineoplastic effect. This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress and EAG1 channel currents were determined in all groups. Our findings showed that combined treatment with IMI and radiotherapy (RAD) did not enhance radiosensitivity of DU145 cells but as unexpected finding, treatment of IMI alone was more effective in DU145 cells.