In vitro genotoxicity and cytotoxicity of a particular combination of pemetrexed and cefixime in human peripheral blood lymphocytes


İSTİFLİ E. S. , TOPAKTAŞ M.

SPRINGERPLUS, cilt.4, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

This study aims to find the genotoxic and cytotoxic effects of a particular combination of pemetrexed (PMX) and cefixime (CFX) in human peripheral blood lymphocytes. Chromosome aberration (CA), sister chromatid exchange (SCE), and micronucleus (MN) tests were used to assess genotoxicity. Whereas, the cytotoxicity was evaluated by using mitotic index (MI), proliferation index (PI), and nuclear division index (NDI). Our tests were proceeded with concentrations of 12.5 + 450, 25 + 800, 37.5 + 1150, and 50 + 1500 mu g/mL of a mixture of PMX and CFX separately for 24 hr and 48 hr.