Effect of tempol (4-hydroxy tempo) on gentamicin-induced nephrotoxicity in rats
FUNDAMENTAL & CLINICAL PHARMACOLOGY, cilt.18, sa.1, ss.79-83, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 1
- Basım Tarihi: 2004
- Doi Numarası: 10.1046/j.0767-3981.2003.00211.x
- Dergi Adı: FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.79-83
- Anahtar Kelimeler: antioxidant, free oxygen species, gentamicin, nephrotoxicity, oxidative stress, tempol, PERMEABLE RADICAL SCAVENGER, ACUTE-RENAL-FAILURE, SUPEROXIDE-DISMUTASE, OXIDANT MECHANISMS, VITAMIN-E, INJURY, KIDNEY, STRESS, IRON, ACID
- Çukurova Üniversitesi Adresli: Evet
Özet
We investigated the effects of tempol (4-hydroxy tempo), a membrane-permeable radical scavenger, on gentamicin-induced renal failure in rats. The rats were given gentamicin (100 mg/kg/day, i.p., once a day); and gentamicin (100 mg/kg/day, i.p.) and tempol (3.5, 7 or 14 mg/kg/day, i.p., once a day). At the end of 7 days, the gentamicin group produced the remarkable nephrotoxicity, characterized by a significantly decreased creatinine clearance and increased serum creatinine, blood urea nitrogen (BUN) and daily urine volume when compared with controls. In control the BUN value was 21.2 +/- 0.07 (mg/100 mL); in comparison, it was 96.9 +/- 6.03 in gentamicin group (P < 0.05). Renal histopathologic examination confirmed acute tubular necrosis in this group. In rats treated with gentamicin and tempol a partial improvement in biochemical and histologic parameters was observed. BUN values were 96.9 &PLUSMN; 6.03 and 36.3 &PLUSMN; 2.39 in gentamicin, and gentamicin plus tempol (14 mg/kg) treated groups, respectively (P < 0.05). These results suggest that the administration of tempol may have a protective effect on gentamicin-induced nephrotoxicity in rats.