Nitric oxide synthase inhibition attenuates vasoactive response to spinal cord stimulation in an experimental cerebral vasospasm model


Goksel H., Karadag O., Turaclar U., Tas F., Oztoprak I.

ACTA NEUROCHIRURGICA, cilt.143, ss.383-391, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 143 Konu: 4
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1007/s007010170094
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Sayfa Sayıları: ss.383-391

Özet

Background. The basic mechanism of delayed cerebral vasospasm following subarachnoid haemorrhage (SAH) has been intensively investigated. II is thought that nitric oxide (NO) is a basic mediator of the cerebral vasodilator mechanism. Previous clinical and experimental studies have shown a cerebral vasodilator effect of high cervical spinal cord stimulation (SCS) however, the mechanism of this effect is still controversial. We investigated the contribution of the vasodilator effect of NO to this mechanism in an experimental SAH model using rabbits.