From Bioactive Pyrrolidino[3,4-c] pyrrolidines to more Bioactive Pyrrolidino[3,4-b] pyrrolidines via Ring-Opening/ Ring-Closing Promoted by Sodium Methoxide
SYNTHESIS-STUTTGART, cilt.51, sa.7, ss.1565-1577, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 7
- Basım Tarihi: 2019
- Doi Numarası: 10.1055/s-0037-1611356
- Dergi Adı: SYNTHESIS-STUTTGART
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1565-1577
- Anahtar Kelimeler: cycloaddition, azomethine ylides, rearrangement, antibacterials, DFT calculations, DERIVATIVES, INDOLE, CYCLOADDITIONS, ANTIBACTERIAL, AGENTS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Çukurova Üniversitesi Adresli: Hayır
Özet
The process involving a rearrangement of pyrrolidino[ 3,4c] pyrrolidine to another pyrrolidino[ 3,4-b] pyrrolidine using sodium methoxide as base is fully studied. The effects of the substituents are analyzed during the ring-opening/ ring-closing sequence. Computational studies are also performed to explain the importance of susbstituents and quaternary carbons, especially when the (3-indolyl) methyl is present in the starting material. Finally, all the samples are evaluated as potential candidates for antibacterial and antimycobacterial activities.