Optimization of lipase-catalyzed synthesis of fructose stearate using response surface methodology

Tukel S., Sahin P. B., YILDIRIM D.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.41, sa.5, ss.344-351, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/21691401.2012.743899
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.344-351
  • Anahtar Kelimeler: Fructose stearate, ionic liquids, response surface methodology, tert-butanol, FATTY-ACID ESTERS, IONIC LIQUIDS, ENZYMATIC-SYNTHESIS, ESTERIFICATION, ACYLATION, SUCROSE, SOLVENT, SYSTEM
  • Çukurova Üniversitesi Adresli: Evet

Özet

In this study, immobilized lipase-catalyzed esterification reaction between fructose and stearic acid was examined for the synthesis of a useful compound, fructose stearate, using response surface methodology. The increase of water content in the reaction medium was the negative effect while the increase in initial stearic acid/fructose molar ratio was the greatest positive effect on the yield. The highest fructose stearate yield was obtained as 65% in tert-butanol. The product yield was enhanced in 1-butyl-3-methylimidazolium trifluoromethanesulfonate obtained as 74% under the optimized conditions. The spectroscopic and elemental analysis methods showed that the esterification reaction is regioselective and the product is fructose monostearate.