Thiopurine S-methyltransferase gene polymorphism in pemphigus vulgaris


Genc A., GÜNAŞTI S. , TULİ A. , ÇÜRÜK M. A. , UZUN S.

POSTEPY DERMATOLOGII I ALERGOLOGII, cilt.29, ss.25-29, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 29 Konu: 1
  • Basım Tarihi: 2012
  • Dergi Adı: POSTEPY DERMATOLOGII I ALERGOLOGII
  • Sayfa Sayıları: ss.25-29

Özet

Introduction: Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes are important as a predictive factor for thiopurine-induced toxicity. Individuals who are TPMT deficient or have intermediate TPMT activity are at risk of developing myelosuppression and life-threatening leucopenia when treated with standard doses of thiopurines; thus, pretreatment identification of these individuals is very important.