Thiopurine S-methyltransferase gene polymorphism in pemphigus vulgaris


Genc A., GÜNAŞTI S. , TULİ A. , ÇÜRÜK M. A. , UZUN S.

POSTEPY DERMATOLOGII I ALERGOLOGII, vol.29, no.1, pp.25-29, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2012
  • Title of Journal : POSTEPY DERMATOLOGII I ALERGOLOGII
  • Page Numbers: pp.25-29

Abstract

Introduction: Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes are important as a predictive factor for thiopurine-induced toxicity. Individuals who are TPMT deficient or have intermediate TPMT activity are at risk of developing myelosuppression and life-threatening leucopenia when treated with standard doses of thiopurines; thus, pretreatment identification of these individuals is very important.