Thiopurine S-methyltransferase gene polymorphism in pemphigus vulgaris

Genc A., GÜNAŞTI S., TULİ A., ÇÜRÜK M. A., UZUN S.

POSTEPY DERMATOLOGII I ALERGOLOGII, vol.29, no.1, pp.25-29, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2012
  • Journal Name: POSTEPY DERMATOLOGII I ALERGOLOGII
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.25-29
  • Çukurova University Affiliated: Yes

Abstract

Introduction: Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes are important as a predictive factor for thiopurine-induced toxicity. Individuals who are TPMT deficient or have intermediate TPMT activity are at risk of developing myelosuppression and life-threatening leucopenia when treated with standard doses of thiopurines; thus, pretreatment identification of these individuals is very important.