POSTEPY DERMATOLOGII I ALERGOLOGII, vol.29, no.1, pp.25-29, 2012 (SCI-Expanded)
Introduction: Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes are important as a predictive factor for thiopurine-induced toxicity. Individuals who are TPMT deficient or have intermediate TPMT activity are at risk of developing myelosuppression and life-threatening leucopenia when treated with standard doses of thiopurines; thus, pretreatment identification of these individuals is very important.