Synthetic Biology-Enabled 3D Bioprinting for Programmable Artificial Tissues and Organs: Progress, Strategies, and Perspectives
Current Stem Cell Reports, cilt.12, sa.1, 2026 (ESCI, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 12 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s40778-026-00261-w
- Dergi Adı: Current Stem Cell Reports
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE, Natural Science Collection (ProQuest), Biological Science Database (ProQuest)
- Anahtar Kelimeler: 3D bioprinting, Genetic circuits, Microenvironmental regulation, Programmable biomaterials, Synthetic biology
- Çukurova Üniversitesi Adresli: Evet
Özet
Purpose of Review: Organ failure remains a leading cause of death, yet organ transplantation cannot meet clinical demand. Although 3D bioprinting enables the fabrication of precise structures, it still lacks programmability and the ability to dynamically regulate. This Review explores how synthetic biology can empower 3D bioprinting to construct functional artificial tissues and organs. Recent Findings: Synthetic biology enables cell programming through genetic circuits, intercellular communication systems, and environmental response mechanisms, while programmable biomaterials support dynamic regulation. Combined with functional enhancement strategies in 3D bioprinting, these advancements have effectively improved tissue structure, maturation, and functional integration. Summary: The convergence of synthetic biology and 3D bioprinting, by coordinating cell programming, material design, and manufacturing strategies, shifts tissue engineering from static constructs toward adaptive, self-regulating living systems. Although challenges remain, this approach offers new insights for the development of artificial tissues and organs with clinical application value. In addition to therapeutic applications, this integration also holds promise for disease modeling, drug screening, and toxicity assessment.