In this study, concentrations of heavy metals were determined in the tissues of fish species (S. solea and S. aurata) and shrimp (P. semiaculatus) from the Yumurtalik zone of the Iskenderun Gulf, Turkey. The aim of of our study is to evaluate potential risks to human health associated with fish and shrimp consumption. Metals concentrations varied significantly depending on the tissues and species. The concentrations of Cu, Fe, Pb and Zn in fish and shrimp tissues were high, while Cd levels were relatively low. In comparing with the permissible limits set by the European Union and Food and Agricultural Organization for fish and shrimp, mean values of Cu, Fe, and Zn were within acceptable limits, but the mean values of Cd and Pb exceeded the limits.