Eight children who have malign diseases such as acute leukemia, lymphoma and hepatoblastoma were included in this preliminary study. All the patients had 1 gram of royal jelly (RJ) before breakfast once a day for one month. During this period complete blood counts, general condition and weights of the patients were recorded. The values of the same patients before and after the use of RJ were examined as controls. The patients did not have GM-CSF and G-CSF while they were having RJ.