Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

GÜRBÜZ F., GURBUZ B. B., CELIK G. G., Yildirim V., UCAKTURK S. A., SEYDAOĞLU G., ...More

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.29, no.1, pp.85-92, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1515/jpem-2015-0171
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.85-92
  • Keywords: appetite, attention deficit and hyperactivity, ghrelin, growth, leptin, methylphenidate, nesfatin-1, DEFICIT/HYPERACTIVITY DISORDER, SERUM LEPTIN, OPEN-LABEL, GHRELIN, HORMONE, NESFATIN-1, PEPTIDE, WEIGHT
  • Çukurova University Affiliated: Yes

Abstract

The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7-14 years. Following treatment, patients' leptin-levels increased and ghrelin levels decreased while no-significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.