Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

GÜRBÜZ F. , GURBUZ B. B. , CELIK G. G. , Yildirim V., UCAKTURK S. A. , SEYDAOĞLU G. , ...More

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.29, no.1, pp.85-92, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1515/jpem-2015-0171
  • Page Numbers: pp.85-92


The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7-14 years. Following treatment, patients' leptin-levels increased and ghrelin levels decreased while no-significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.