Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.29, sa.1, ss.85-92, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 1
- Basım Tarihi: 2016
- Doi Numarası: 10.1515/jpem-2015-0171
- Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.85-92
- Anahtar Kelimeler: appetite, attention deficit and hyperactivity, ghrelin, growth, leptin, methylphenidate, nesfatin-1, DEFICIT/HYPERACTIVITY DISORDER, SERUM LEPTIN, OPEN-LABEL, GHRELIN, HORMONE, NESFATIN-1, PEPTIDE, WEIGHT
- Çukurova Üniversitesi Adresli: Evet
Özet
The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7-14 years. Following treatment, patients' leptin-levels increased and ghrelin levels decreased while no-significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.