Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder


GÜRBÜZ F. , GURBUZ B. B. , CELIK G. G. , Yildirim V., UCAKTURK S. A. , SEYDAOĞLU G. , et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.29, ss.85-92, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 29 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/jpem-2015-0171
  • Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Sayfa Sayısı: ss.85-92

Özet

The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7-14 years. Following treatment, patients' leptin-levels increased and ghrelin levels decreased while no-significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.