TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.32, no.1, pp.193-200, 2012 (SCI-Expanded)
Objective: High tissue levels of free oxygen radicals (FORs) have been reported in corrosive esophagitis (CE). The present study aimed to determine whether prediction of injury and late complications in CE is possible based on blood levels of FORs, Interleukin (IL)-6, Tumor necrosis factor (TNF)-alpha, and IL-10. Material and Methods: Forty-two male Wistar albino rats were randomly divided into 2 main groups (A and B), each consisting of 3 subgroups (A1, A2, A3, B1, B2, and B3) of equal number. To induce experimental CE 17.5% NaOH was used in subgroups A2 and B2, and 37.5% NaOH in subgroups A3 and B3. The sham groups (Al and B1) received 0.9% NaCl. Blood levels of lipid hydroperoxide (LPO) and glutathione peroxidase (GPx) were measured in group A. Blood levels of IL-6, IL-10, and TNF-alpha were measured in group B. Esophageal samples for histopathological evaluation were obtained following scarification after 3 weeks. Results: There were significant differences between the sham subgroups and CE subgroups, regarding histopathological scores (p< 0.05). There was no significant difference between the groups in blood levels of LPO, GPX, TNF-alpha or IL-10 (p> 0.05). There were significant differences between severe CE subgroups and the sham subgroups, based on IL-6 values (p= 0,007). Conclusion: In contrast to previous reports, which demonstrated increased tissue levels of FORs, blood levels of FORs were not high in this study. Nonetheless, in the light of the observed differences in IL-6 levels between the subgroups, we suggest that injury and late complications of CE may be predicted following additional experimental and clinical research using biochemical methods.