FLOW CYTOMETRIC DNA ANALYSIS IN PRIMARY GASTROINTESTINAL LYMPHOMA

PAYDAS S., DINCOL D., GILMANSACHS A., TUNCER İ., ZORLUDEMIR S., ERSOZ C., ...Daha Fazla

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, cilt.13, sa.3, ss.229-232, 1994 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 3
  • Basım Tarihi: 1994
  • Dergi Adı: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.229-232
  • Çukurova Üniversitesi Adresli: Evet

Özet

Formalin-fixed and paraffin-embedded biopsy specimens from twenty-six patients with primary gastrointestinal lymphoma were evaluated by DNA flow cytometry. Nineteen of 26 samples (73%) had diploid DNA content and 7 (27%) had aneuploid DNA pattern. Proliferative (S phase) fraction in diploid samples ranged between 7-24.6% and the DNA index in aneuploid samples ranged between 1.3-2.3. Four of 10 low grade and 3 of 6 intermediate grade lymphomas had aneuploid DNA content, whereas none of the high grade lymphomas (0/10) had aneuploid DNA patterns (p < 0.05). The results suggest that aneuploidy may be a good prognostic indicator in primary gastrointestinal lymphoma.