The relationship between acute coronary artery diseases with c-reactive protein+1059 G/C and angiotensin-converting enzyme I/D gene polymorphisms


DURAN G. G. , FANSA İ., DURAN N., Jenedi K., Onlen C., MİRALOĞLU M. , ...More

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol.9, no.10, pp.20126-20136, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 10
  • Publication Date: 2016
  • Title of Journal : INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
  • Page Numbers: pp.20126-20136

Abstract

Objective: The purpose of this study was to evaluate the presence of an association between the CRP + 1059 G/C and ACE I/D gene polymorphisms and patients who were diagnosed to have acute coronary syndrome and underwent coronary angiography. Methods: A total of 126 patients (mean age: 60.0 +/- 12.9) and 144 healthy individuals (mean age: 52.1 +/- 13.0) were included to this study. The presence of CRP + 1059 G/C and ACE I/D gene polymorphisms were analyzed using the RFLP method. Results: When the patient and control groups were evaluated in terms of ACE I/D gene polymorphism, no statistically significant difference was found in the frequency of ACE DD and ACE ID between the two groups (P>0.05), while the percentage of ACE II genotype was statistically significantly higher in the patient group compared with the control group (P<0.032). For the distribution of CRP G/C genotype; CRP GG, CRP GC and CRP CC genotype frequencies were similar in the patient and control groups (P>0.05). When the presence of the ACE I/D genotype and CRP G/C genotype was compared in patients with vessel disease (one vessel, two vessels and three vessels) among the patients with coronary artery diseases with the control group, statistically significant differences were found between the two groups (P<0.05). In addition, the frequency of the ACE I/D genotype in hypertensive patients with coronary artery disease was statistically significantly higher (P<0.033). Also, the frequency of the CRP + 1059 G/C genotype was found to be statistically significantly higher in the patient group (P<0.026). Conclusion: This study demonstrated that CRP + 1059 G/C and ACE I/D gene polymorphisms may be a genetic marker associated with coronary artery disease in patients diagnosed with ACS.