Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents

Serbetci, TUBA; Genes, Constance; Depauw, Sabine; Prado, Soizic; Poree, Francois-Hugues; Hildebrand, Marie-Paule; David-Cordonnier, Marie-Helene; Michel, Sylvie; Tillequin, Francois

doi:10.1016/j.ejmech.2010.02.043

Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents

Atıf İçin Kopyala

Serbetci T., Genes C., Depauw S., Prado S., Poree F., Hildebrand M., ...Daha Fazla

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.45, sa.6, ss.2547-2558, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 45 Sayı: 6
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.ejmech.2010.02.043
Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2547-2558
Çukurova Üniversitesi Adresli: Hayır

Özet

Benzo[c][1,7] and [1,8]phenanthroline substituted by dialkylaminoalkyl side chains at position C2 and C1, respectively, were synthesized and their biological activity evaluated. These compounds displayed more potent cytotoxicity toward L1210 cells than the parent unsubstituted compounds, associated with strong DNA interaction. The moderate Topol inhibitory activity induced by the novel compounds suggests that other cellular targets should be responsible for the antiproliferative activity.