The effect of progesterone on total brain tissue sialic acid levels in experimental epilepsy

Pence S., BOŞNAK M., Kurtul N., UĞUR M. G. , ERKUTLU İ., BAĞCI C., ...Daha Fazla

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.118, ss.105-118, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 118 Konu: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/00207450601044611
  • Sayfa Sayıları: ss.105-118


Epilepsy, the most common neurological disorder worldwide, changing cellular interactions and connectivity may have effects on sialic acid levels. A total of 80 mice Were separated into 8 groups: the sham, control, pentylentetrazole (PTZ), PTZ plus progesterone, five dose progesterone, single dose progesterone, kindling, and kindling plus progesterone groups. Brains of each mice were extracted and were divided into five parts. The sialic acid levels were significantly different between the groups and also in the subgroups. The results suggested that progesterone may have an anti-seizure effect by decreasing sialic acid levels in mice. Further studies are needed to evaluate the role of progesterone on sialic acid levels and its role in the epilepsy pathogenesis.