Akademik Veri Yönetim Sistemi
Istanbul Journal of Pharmacy, cilt.53, sa.1, ss.27-38, 2023 (Hakemli Dergi)
Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influenza, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobotanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose (HPMC). The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demonstrated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.