The aim of this study is to demonstrate the effects of water shortage, which may occur in different periods, on wheat grain yield and quality. One of the most important factors limiting wheat yield in the Southeastern Anatolia Region of Turkey is drought, which is caused by inadequate precipitation and irregular distribution over the year. Four different bread and durum wheat cultivars (Sancanak-98, Firat-93, Pehlivan, Ceyhan-99), which are widely cultivated in the region, were used as the material of the study. The experiment was carried out with 3 replications, according to the random blocks design. The research was carried out under greenhouse conditions. The effects of four different drought conditions on the wheat's development, yield and mineral content were investigated under irrigation (K0), early drought (K1), late drought (K2) and full drought (K3). According to the results, a 9.12% loss in chlorophyll content was observed under irrigated conditions (K0). 21.68% leaf area, 28.98% plant green area, and 52.09% plant height declines were recorded. The amount of potassium (K) was found to change between 2.86 mg (K3) and 34.77 mg (K2), while the amount of calcium (Ca) changed between 0.67 mg (K3) and 33.23 mg (K3) and the amount of sodium (Na) changed between 0.20 mg (K1) and 27.05 mg (K0) in the root and stem of plants.