A rare genetic disorder in the differential diagnosis of the entrapment neuropathies: Hereditary neuropathy with liability to pressure palsies


Koc F., Guzel R. , Benlidayi I. , Yerdelen D., Guzel I., Sarica Y.

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, vol.12, no.2, pp.78-82, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1097/01.rhu.0000208634.26253.17
  • Title of Journal : JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
  • Page Numbers: pp.78-82

Abstract

Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal-dominant, slowly progressive neuromuscular disorder, which is characterized by recurrent acute peripheral nerve palsies. Electrophysiological studies show decreased motor and sensory conduction velocities in both clinically affected and unaffected nerves. Focal thickening of myelin sheath with sausage-like formation, also called tomacula, is seen in nerve biopsies. In genetic studies, 1.5-Mb deletion on chromosome 17p 11.2 is detected in approximately 85% of HNPP cases and point mutations are determined in some cases.