The effect of vitamin E and L-carnitine against methotrexate-induced injury in rat testis

YÜNCÜ M., Bukucu N., Bayat N., SENCAR L., Tarakcioglu M.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.3, ss.517-525, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1409-39
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.517-525
  • Anahtar Kelimeler: Testes, methotrexate, vitamin E, L-carnitine, rat, INDUCED TESTICULAR TOXICITY, ACID PHENETHYL ESTER, OXIDATIVE ORGAN INJURY, LIPID-PEROXIDATION, LUMINAL FLUID, GERM-CELLS, MAMMALS, MICE, AMELIORATION, CYTOTOXICITY
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background/aim: Methotrexate (MTX), used commonly as an antimetabolite drug in cancer therapy, leads to acute toxic side effects in tissues or organs containing rapidly dividing cells, such as bone marrow, gastrointestinal mucosa, and seminiferous tubules. In this study, we investigated the protective effects of vitamin E and L-carnitine against MTX-induced injury in rat testis.