The effect of vitamin E and L-carnitine against methotrexate-induced injury in rat testis


YÜNCÜ M., Bukucu N., Bayat N., SENCAR L. , Tarakcioglu M.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, ss.517-525, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1409-39
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayısı: ss.517-525

Özet

Background/aim: Methotrexate (MTX), used commonly as an antimetabolite drug in cancer therapy, leads to acute toxic side effects in tissues or organs containing rapidly dividing cells, such as bone marrow, gastrointestinal mucosa, and seminiferous tubules. In this study, we investigated the protective effects of vitamin E and L-carnitine against MTX-induced injury in rat testis.