In Turkey, herbicide active ingredient (a.i.) was used approximately 25% in pesticide applications in 2007. In Adana province, Turkey, 10 numbers of active ingredients were used for weed control in wheat cultivation areas in 2007. These are: fenoxaprop-p-ethyl, clodinafop-propargyl, mesosulfuronmethyl, iodosulfuron-methyl-sodium, florasulam, flumetsulam, 2,4-D acid dimethylamin, tribenuron-methyl, triasulfuron and dicamba. In this study, total risk of herbicide on human health and environment were assessed by POCER (The Pesticide Occupational and Environmental Risk) indicator. In this study, it was obtained that clodinafop-propargyl a.i. has high potential risk for worker (1.000) and operator (0.909) due to 1.000 of maximum EF values. Flumetsulam a.i, and triasulfuron a.i. have no total risk for human health and environment due to 0 EF values in all risk indicators. In this study, it was shown that human health has been affected higher than environment in herbicide applications. It was determined that risk for human health contains 88.7% of total risk values in herbicide application for wheat cultivation areas. It was shown that, in this study, some factors affecting proper application of herbicides such as application techniques and equipment, meteorological conditions and application doses should be taken into account for protecting of human health and environment.