Effects of caffeine on neuronal apoptosis in neonatal hypoxic-ischemic brain injury

Kilicdag H., DAĞLIOĞLU Y. K., ERDOĞAN Ş., ZORLUDEMİR S.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.27, sa.14, ss.1470-1475, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 14
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/14767058.2013.878694
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1470-1475
  • Anahtar Kelimeler: Apoptosis, brain injury, caffeine, hypoxia, ischemia, CHRONIC INTERMITTENT HYPOXIA, ADENOSINE RECEPTORS, SLEEP-APNEA, TNF-ALPHA, IN-VIVO, RAT, NEUROPROTECTION, ENCEPHALOPATHY, EXPRESSION, NEWBORN
  • Çukurova Üniversitesi Adresli: Evet

Özet

Objective: Hypoxia-ischemia (HI) in rat pups leads to strong activation of apoptosis, and apoptosis contributes significantly to cerebral damage in the perinatal period. Caffeine displays a broad array of actions on the brain. The aim of this study was to investigate the effects of caffeine on neuronal apoptosis in a hypoxic-ischemic neonatal model.