Effects of caffeine on neuronal apoptosis in neonatal hypoxic-ischemic brain injury

Kilicdag H., DAĞLIOĞLU Y. K. , ERDOĞAN Ş. , ZORLUDEMİR S.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.27, ss.1470-1475, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27 Konu: 14
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/14767058.2013.878694
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Sayfa Sayıları: ss.1470-1475

Özet

Objective: Hypoxia-ischemia (HI) in rat pups leads to strong activation of apoptosis, and apoptosis contributes significantly to cerebral damage in the perinatal period. Caffeine displays a broad array of actions on the brain. The aim of this study was to investigate the effects of caffeine on neuronal apoptosis in a hypoxic-ischemic neonatal model.