Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever


OZTURK B., Kuscu F. , TUTUNCU E., SENCAN I., GURBUZ Y., TUZUN H.

JOURNAL OF CLINICAL VIROLOGY, cilt.47, ss.115-119, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 47 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jcv.2009.10.015
  • Dergi Adı: JOURNAL OF CLINICAL VIROLOGY
  • Sayfa Sayısı: ss.115-119

Özet

Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease. Pathogenesis of the disease has not been well described yet. A well-known pathogenic feature of CCHF virus is its capability to damage endothelium. Increased hyaluronic acid (HA) levels indicate liver sinusoidal endothelial damage. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and vascular endothelial growth factor-A (VEGF-A) play a role in the inflammatory process, vascular damage and plasma leakage.