Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever

OZTURK, Baris; Kuscu, FERİT; TUTUNCU, Ediz; SENCAN, Irfan; GURBUZ, Yunus; TUZUN, Hakan

doi:10.1016/j.jcv.2009.10.015

Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever

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OZTURK B., Kuscu F., TUTUNCU E., SENCAN I., GURBUZ Y., TUZUN H.

JOURNAL OF CLINICAL VIROLOGY, vol.47, no.2, pp.115-119, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 47 Issue: 2
Publication Date: 2010
Doi Number: 10.1016/j.jcv.2009.10.015
Journal Name: JOURNAL OF CLINICAL VIROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.115-119
Çukurova University Affiliated: No

Abstract

Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease. Pathogenesis of the disease has not been well described yet. A well-known pathogenic feature of CCHF virus is its capability to damage endothelium. Increased hyaluronic acid (HA) levels indicate liver sinusoidal endothelial damage. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and vascular endothelial growth factor-A (VEGF-A) play a role in the inflammatory process, vascular damage and plasma leakage.