Short-term effects of fluvastatin therapy on plasma interleukin-10 levels in patients with chronic heart failure

TEKİN A., SEZGİN N., Katircibasi M. T., Tekin G., Cokesen Y., Sezgin A. T., ...More

CORONARY ARTERY DISEASE, vol.19, no.7, pp.513-519, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 7
  • Publication Date: 2008
  • Doi Number: 10.1097/mca.0b013e32830d27d2
  • Journal Name: CORONARY ARTERY DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.513-519
  • Çukurova University Affiliated: No

Abstract

Background Experimental data demonstrated that inflammatory mediators, such as pro-inflammatory and anti-inflammatory cytokines and their receptors might have important role in the development and the progression of heart failure (HF). Statins were shown to downregulate inflammatory cytokines in HE Interleukin (IL)-10 is one of the most important anti-inflammatory cytokines. The effect of statin therapy on plasma IL-10 levels is not known in patients with HE We conducted this study to investigate the effects of fluvastatin therapy on plasma IL-10 cytokine concentration in patients with HE