Instruments for determining clinically relevant fatigue in breast cancer patients during radiotherapy


ANDİÇ F., Miller A. H., Brown G., Chu L., Lin J., Liu T., ...Daha Fazla

BREAST CANCER, cilt.27, sa.2, ss.197-205, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s12282-019-01008-8
  • Dergi Adı: BREAST CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.197-205
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background This study aimed to determine radiotherapy (RT)-related changes in cancer-related fatigue (CRF), using Multidimensional Fatigue Inventory-20 (MFI-20), and fatigue-intensity rating (FIR) instruments at three different timepoints and to identify the optimal thresholds of MFI-20 scores which would correlate with moderate-to-severe fatigue warranting an intervention in breast cancer patients treated with RT. Methods Eighty-eight breast cancer patients treated with surgery followed by RT were included in the study. CRF was assessed with both FIR and MFI-20 tools at three different timepoints: within the week prior to RT (pre-RT), last week of RT, and 6 weeks after RT completion (post-RT). Changes in measurements, correlations between measurements and optimal cutpoints of MFI-20 scores were analyzed. Results While FIR scores significantly changed over time (eta(2): 0.179), changes in MFI-20 scores were relatively small (eta(2): 0.076). Comparisons of the last week of RT versus post-RT scores showed small-to-moderate decrease for MFI-20 and FIR. FIR and MFI-20 scores were correlated at all timepoints and most correlated during and after RT (r = 0.525 95%CI 0.346-0.667, r = 0.791 95%CI 0.692-0.860 and r = 0.716 95%CI 0.589-0.808, respectively). Furthermore, the most correlated MFI-20 subscale with FIR was general fatigue (r = 0.603 95%CI 0.442-0.725, r = 0.821 95%CI 0.734-0.881 and r = 0.754 95%CI 0.641-0.835, respectively). Optimal cutpoints of the MFI-20 total scores corresponding to FIR scores >= 4 was 43.5 for all timepoints and the MFI total scores corresponding to FIR score >= 7 were 53.5, 52.5 and 60.5, respectively. Conclusions MFI-20 and FIR scores are highly correlated measures of CRF among breast cancer patients treated with RT. An MFI-20 score of >= 43.5 is suggested as a clinically significant score indicating moderate-to-severe fatigue, while an MFI score of >= 52.5 is indicative of severe fatigue.