Protective Role of Simvastatin on Lung Damage Caused by Burn and Cotton Smoke Inhalation in Rats


Belli S., Basaran O., ÖZDEMİR B. H. , Turkoglu S., Karabay G., KUT A., ...More

JOURNAL OF SURGICAL RESEARCH, vol.167, no.2, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 167 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jss.2010.01.035
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH

Abstract

Background. Smoke inhalation injury is a major comorbid factor in patients with thermal injury and occurs in about 30% of patients with major burns. In addition, inhalation injury reportedly accounts for 20%-84% of the mortality in burned individuals and is associated with higher mortality rates for every age and burn size category. The aim of the present study was to investigate the effects of simvastatin on lung damage with burn and cotton smoke inhalation.