High-dose verapamil plus trandolapril-induced thrombotic microangiopathy

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GOKEL Y., Paydas S., ACIKALIN A., BOZKURT A.

HAEMATOLOGIA, cilt.32, sa.3, ss.281-285, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1163/15685590260461101
  • Dergi Adı: HAEMATOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.281-285
  • Çukurova Üniversitesi Adresli: Evet

Özet

Thrombotic microangiopathy (TMA) is a syndrome characterized by microangiopathic haemolytic anaemia, thrombocytopenia, and several variable signs of organ damage due to the platelet thrombi in the microcirculation. This article reports a case with TMA which developed after ingestion of a high-dose combination of verapamil and trandolapril. To the authors' knowledge, no prior cases of TMA induced by trandolapril (an angiotensin-converting enzyme inhibitor) and verapamil (a calcium channel blocker) have been reported in the literature.