Evaluation of KIR genes in recurrent miscarriage


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Ozturk O. G., SAHIN G., KARACOR E. D. Z., KUCUKGOZ U.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, vol.29, no.9, pp.933-938, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1007/s10815-012-9811-1
  • Journal Name: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.933-938
  • Keywords: Killer cellimmunoglobulin-like receptors, KIR, Natural killer cells, Recurrent miscarriage, Trophoblast, NATURAL-KILLER-CELLS, IMMUNOGLOBULIN-LIKE RECEPTORS, CLASS-I MOLECULES, SPONTANEOUS-ABORTION, HLA-C, HUMAN-PREGNANCY, WOMEN, RECOGNITION, ASSOCIATION, REPERTOIRE
  • Çukurova University Affiliated: Yes

Abstract

Natural killer (NK) cells express killer immunoglobulin-like receptors (KIRs) which recognize HLA class I molecules on trophoblasts. KIRs could either activate NK cells or inhibit them to produce soluble factors necessary for the maintenance of pregnancy, thus they are suspected of being involved in the causes of recurrent miscarriage. The aim of this study was to evaluate whether there is any possible association between KIR genes, genotypes and recurrent miscarriage.