Evaluation of KIR genes in recurrent miscarriage

Creative Commons License

Ozturk O. G., SAHIN G., KARACOR E. D. Z., KUCUKGOZ U.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.29, sa.9, ss.933-938, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10815-012-9811-1
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.933-938
  • Anahtar Kelimeler: Killer cellimmunoglobulin-like receptors, KIR, Natural killer cells, Recurrent miscarriage, Trophoblast, NATURAL-KILLER-CELLS, IMMUNOGLOBULIN-LIKE RECEPTORS, CLASS-I MOLECULES, SPONTANEOUS-ABORTION, HLA-C, HUMAN-PREGNANCY, WOMEN, RECOGNITION, ASSOCIATION, REPERTOIRE
  • Çukurova Üniversitesi Adresli: Evet

Özet

Natural killer (NK) cells express killer immunoglobulin-like receptors (KIRs) which recognize HLA class I molecules on trophoblasts. KIRs could either activate NK cells or inhibit them to produce soluble factors necessary for the maintenance of pregnancy, thus they are suspected of being involved in the causes of recurrent miscarriage. The aim of this study was to evaluate whether there is any possible association between KIR genes, genotypes and recurrent miscarriage.