Evaluation of KIR genes in recurrent miscarriage


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Ozturk O. G. , SAHIN G., KARACOR E. D. Z. , KUCUKGOZ U.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.29, ss.933-938, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 29 Konu: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10815-012-9811-1
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Sayfa Sayısı: ss.933-938

Özet

Natural killer (NK) cells express killer immunoglobulin-like receptors (KIRs) which recognize HLA class I molecules on trophoblasts. KIRs could either activate NK cells or inhibit them to produce soluble factors necessary for the maintenance of pregnancy, thus they are suspected of being involved in the causes of recurrent miscarriage. The aim of this study was to evaluate whether there is any possible association between KIR genes, genotypes and recurrent miscarriage.