Is it reliable to use paraffin embedded tumor tissues as biological evidence in parentage cases?

CANAN, HÜSNİYE; SERİN, AYŞE

doi:10.1016/j.fsigss.2019.09.121

Is it reliable to use paraffin embedded tumor tissues as biological evidence in parentage cases?

Atıf İçin Kopyala

CANAN H., SERİN A.

FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES, cilt.7, sa.1, ss.318-319, 2019 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 7 Sayı: 1
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.fsigss.2019.09.121
Dergi Adı: FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Criminal Justice Abstracts, EMBASE
Sayfa Sayıları: ss.318-319
Çukurova Üniversitesi Adresli: Evet

Özet

Short tandem repeats (STR) are reliable markers used for forensic identification and paternity testing. In some cases, histological paraffin blocks containing malignant cells can be used for STR typing in identification and paternity. DNA profiling and result interpretation with these samples often becomes a challenging job. The malignant tissues may show preferential amplification, loss of heterozygosity, and microsatellite instability.