Is it reliable to use paraffin embedded tumor tissues as biological evidence in parentage cases?


CANAN H. , SERİN A.

FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES, cilt.7, ss.318-319, 2019 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 7 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.fsigss.2019.09.121
  • Dergi Adı: FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES
  • Sayfa Sayısı: ss.318-319

Özet

Short tandem repeats (STR) are reliable markers used for forensic identification and paternity testing. In some cases, histological paraffin blocks containing malignant cells can be used for STR typing in identification and paternity. DNA profiling and result interpretation with these samples often becomes a challenging job. The malignant tissues may show preferential amplification, loss of heterozygosity, and microsatellite instability.