Electron and light microscopic evaluation of effects of the Lapatinib on rat ovary and uterus

Muslu H. T., KUYUCU Y., METE U. Ö.

CUKUROVA MEDICAL JOURNAL, vol.45, no.3, pp.921-932, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.17826/cumj.691891
  • Journal Name: CUKUROVA MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.921-932
  • Çukurova University Affiliated: Yes

Abstract

Purpose: Many drugs, started to be used in targeted anticancer treatment as a result of advances in molecular oncology, stop proliferation of tumor cells via interacting with cell receptors and intracellular signaling molecules. Because of physiological functions of these targets, adverse effects develop during therapy. Lapatinib is one of the drugs used in targeted therapies, enters into the cell and inhibits the activity of epidermal growth factor and receptor-linked tyrosine kinase. Our study aimed to investigate changes in uterine and ovarian tissues of rats caused by Lapatinib at biochemical, light and electron microscopic levels.