Killer Cell Immunoglobulin-Like Receptor (KIR) Genotype Distribution in Familial Mediterranean Fever (FMF) Patients

Erken E., Ozturk O. G., KUDAS O., TAS D. A., Demirtas A., KİBAR F., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.21, ss.3547-3554, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21
  • Basım Tarihi: 2015
  • Doi Numarası: 10.12659/msm.895211
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3547-3554
  • Anahtar Kelimeler: Amyloidosis, Familial Mediterranean Fever, Genotype, Killer Cells, Natural, Receptors, KIR, C-REACTIVE PROTEIN, ANKYLOSING-SPONDYLITIS, POLYMORPHISMS, ASSOCIATION, DISEASE, GENES, ALLELES, RISK
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease predominantly affecting Mediterranean populations. The gene associated with FMF is the MEFV gene, which encodes for a protein called pyrin. Mutations of pyrin lead to uncontrolled attacks of inflammation, and subclinical inflammation continues during attack-free intervals. Killer cell immunoglobulin-like receptor (KIR) genes encode HLA class I receptors expressed by NK cells. The aim this study was to look for immunogenetic determinants in the pathogenesis of FMF and find out if KIR are related to susceptibility to disease or complications like renal amyloidosis.