Estrogen receptor alpha (Esr1) regulates aromatase (Cyp19a1) expression in the mouse brain

Yilmaz M. B., Zhao H., Brooks D. C., Fenkci I. V., Imir-Yenicesu G., Attar E., ...Daha Fazla

NEUROENDOCRINOLOGY LETTERS, cilt.36, sa.2, ss.178-182, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 2
  • Basım Tarihi: 2015
  • Dergi Adı: NEUROENDOCRINOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.178-182
  • Anahtar Kelimeler: aromatase, mouse brain, hypothalamus, estrogen receptor, estradiol, Esr1KO mouse, MESSENGER-RNA, TESTOSTERONE, REGION
  • Çukurova Üniversitesi Adresli: Evet

Özet

OBJECTIVES: Local estrogen production in the brain regulates critical functions including neuronal development, gonadotropin secretion and sexual behavior. In the mouse brain, a 36 kb distal promoter (l.f) regulates the Cyp19a1 gene that encodes aromatase, the key enzyme for estrogen biosynthesis. In vitro, promoter l.f interacts with estrogen receptor alpha (Esr1) to mediate Cyp19a1 mRNA expression and enzyme activity in mouse hypothalamic neuronal cell lines. The in vivo mechanisms that control mammalian brain aromatase expression during fetal and adult development, however, are not thoroughly understood. Our aim was to elucidate the basis of the in vivo connection between Esr1 and Cyp19a1.