Refractory breast cancer: A comparison of two different chemotherapy regimens

Erkisi M., Bilkay B., Seyrek E., Hazar B., Burgut R.

JOURNAL OF CHEMOTHERAPY, vol.9, no.6, pp.442-445, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 6
  • Publication Date: 1997
  • Doi Number: 10.1179/joc.1997.9.6.442
  • Title of Journal : JOURNAL OF CHEMOTHERAPY
  • Page Numbers: pp.442-445


Sixty metastatic and recurrent breast cancer patients who had been given cyclophosphamide, methotrexate and fluorouracil (CMF) therapy previously and were treated at the Oncology Departments of Cukurova and Ege University Medical Schools between March 1992-94, were randomized into 2 groups for the chemotherapy program, The 30 patients in the Ist group were given etoposide: 200 mg x day x 5 days orally every 3 weeks. The 30 patients of the 2nd group were given fluorouracil: 500 mg x m(2), doxorubicin: 50mg/m(2), cyclophosphamide: 500 mg/m(2) intravenously every 3 weeks, The response rates were 21/30 in group 1 and 17/30 in group 2. The median duration of responses was 11 months (8-21) in the Ist and 3 months (4-18) in the 2nd group. Severe myelotoxicity was observed in 2 of the patients in the Ist group and in 5 of the patients in the 2nd group.