Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behcet's disease

CANATAROGLU A., TANRIVERDI K., INAL T. C. , Seydaoglu G. , ARSLAN D., OZBEK S. , ...Daha Fazla

RHEUMATOLOGY INTERNATIONAL, cilt.23, ss.236-240, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 5
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/s00296-003-0301-8
  • Sayfa Sayıları: ss.236-240


Objective. The aim of this study was to assess whether homozygosity for the 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T mutation and plasma homocysteine concentration are related to deep vein thrombosis in Behcet's disease (BD) patients. Methods. Forty BD patients (23 males, 17 females; mean age 40.2+/-8.4 years) and 60 healthy controls (HC) (34 males, 26 females; mean age 41.6+/-6.9 years) were included in the study. Fourteen of the BD patients had a history of deep venous thrombosis (DVT), as confirmed by Doppler ultrasound. Results. The rates of homozygosity for the MTHFR C677T mutation in the BD and HC groups were 7.5% and 10%, respectively. The distribution of MTHFR genotypes was similar in the two groups (p>0.05), and analysis showed that homozygosity for the mutation was not a risk factor for DVT. The mean plasma homocysteine levels were 13.4+/-4.2 mumol/l for the overall BD patients and 12.6+/-3.8 mumol/l for HC (p>0.05). However, the mean plasma homocysteine level in the BD patients with DVT history (15.9+/-4.6 mumol/l) was significantly higher than the level in the BD patients with no DVT history (12.1+/-3.3 mumol/l) (p=0.013) and the level in the HC group (12.6+/-3.8 mumol/l) (p=0.025). Conclusion. The study results suggest that elevated plasma homocysteine level may play a role in the pathogenesis of venous thrombosis in BD.