Lack of an association of programmed cell death-1 PD1.3 polymorphism with risk of hepatocellular carcinoma susceptibility in Turkish population: A case-control study

BAYRAM S., AKKIZ H. , Ulger Y., Bekar A., Akgollu E., Yildirim S.

GENE, cilt.511, ss.308-313, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 511 Konu: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.gene.2012.09.119
  • Dergi Adı: GENE
  • Sayfa Sayıları: ss.308-313


Aim: The programmed cell death-1 (PD-1) is a potent immunoregulatory molecule which is responsible for the negative regulation of T-cell activation and peripheral tolerance. Recently, overexpression of PD-1 has been reported to contribute to immune system evasion and poor survival of hepatocellular carcinoma (HCC). A common single nucleotide polymorphism in intron 4 of PD-1 gene called PD-1.3 has been reported to influence PD-1 expression, but its association with HCC has yet to be investigated. The aim of the present study was to investigate whether this polymorphism could be involved in the risk of HCC susceptibility.